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Adeno-Associated Virus Capsid Proteins May Play a Role in Transcription and Second-Strand Synthesis of Recombinant Genomes

A group of four interacting amino acids in adeno-associated virus type 8 (AAV8) called the pH quartet has been shown to undergo a structural change when subjected to acidic pH comparable to that seen in endosomal compartments. We examined the phenotypes of mutants with mutations in these amino acids...

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Autors principals: Salganik, Maxim, Aydemir, Fikret, Nam, Hyun-Joo, McKenna, Robert, Agbandje-McKenna, Mavis, Muzyczka, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911664/
https://ncbi.nlm.nih.gov/pubmed/24198419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02093-13
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