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Roles of chromophore and apo-protein in neocarzinostatin action.

The methanol-extractable, nonprotein chromophore of the antitumor, protein antibiotic neocarzinostatin (NCS) has at least the full activity of the parent compound in inhibiting DNA synthesis and growth of HeLa cells and in causing DNA strand breaks in vivo and in vitro. In vitro DNA strand scission...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kappen, L S, Napier, M A, Goldberg, I H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6445563/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.1970
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