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Activation of neocarzinostatin chromophore and formation of nascent DNA damage do not require molecular oxygen.

Thiol-activated neocarzinostatin chromophore abstracts tritium from the 5', but not from the 1' or 2' positions of deoxyribose in DNA and incorporates it into a stable, non-exchangeable form. The abstracted tritium remains covalently associated with the chromophore or its degradation product after t...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kappen, L S, Goldberg, I H
Format: Artigo
Language:Inglês
Published: Oxford University Press 1985
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341101/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3158880/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/13.5.1637
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