Spontaneous generation of a biradical species of neocarzinostatin chromophore: role in DNA bulge-specific cleavage.

Detailed structure determination of the major and minor base-catalyzed degradation products of the chromophore of the enediyne anticancer antibiotic neocarzinostatin in the absence of DNA demonstrates that the enolate Michael addition reaction leading to a spirolactone cumulene intermediate is a spo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hensens, O D, Chin, D H, Stassinopoulos, A, Zink, D L, Kappen, L S, Goldberg, I H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183944/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4534
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