Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

Cystic fibrosis (CF) is caused by the functional expression defect of the CF transmembrane conductance regulator (CFTR) chloride channel at the apical plasma membrane. Impaired bacterial clearance and hyperactive innate immune response are hallmarks of the CF lung disease, yet the existence of and m...

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Main Authors: Veit, Guido, Bossard, Florian, Goepp, Julie, Verkman, A. S., Galietta, Luis J. V., Hanrahan, John W., Lukacs, Gergely L.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484098/
https://ncbi.nlm.nih.gov/pubmed/22973054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-06-0424
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