Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (Tα-1) was proposed as a single molecule-based...

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Vydáno v:Sci Rep
Hlavní autoři: Armirotti, Andrea, Tomati, Valeria, Matthes, Elizabeth, Veit, Guido, Cholon, Deborah M., Phuan, Puay-Wah, Braccia, Clarissa, Guidone, Daniela, Gentzsch, Martina, Lukacs, Gergely L., Verkman, Alan S., Galietta, Luis J. V., Hanrahan, John W., Pedemonte, Nicoletta
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635361/
https://ncbi.nlm.nih.gov/pubmed/31311979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46639-1
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