Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

The most common cause of cystic fibrosis (CF) is deletion of phenylalanine 508 (ΔF508) in the CF transmembrane conductance regulator (CFTR) chloride channel. The ΔF508 mutation produces defects in folding, stability, and channel gating. To identify small-molecule correctors of defective cellular pro...

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Hlavní autoři: Pedemonte, Nicoletta, Lukacs, Gergely L., Du, Kai, Caci, Emanuela, Zegarra-Moran, Olga, Galietta, Luis J.V., Verkman, A.S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2005
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190372/
https://ncbi.nlm.nih.gov/pubmed/16127463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24898
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