Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

The most common cause of cystic fibrosis (CF) is deletion of phenylalanine 508 (ΔF508) in the CF transmembrane conductance regulator (CFTR) chloride channel. The ΔF508 mutation produces defects in folding, stability, and channel gating. To identify small-molecule correctors of defective cellular pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pedemonte, Nicoletta, Lukacs, Gergely L., Du, Kai, Caci, Emanuela, Zegarra-Moran, Olga, Galietta, Luis J.V., Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190372/
https://ncbi.nlm.nih.gov/pubmed/16127463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24898
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados