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Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening
The most common cause of cystic fibrosis (CF) is deletion of phenylalanine 508 (ΔF508) in the CF transmembrane conductance regulator (CFTR) chloride channel. The ΔF508 mutation produces defects in folding, stability, and channel gating. To identify small-molecule correctors of defective cellular pro...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1190372/ https://ncbi.nlm.nih.gov/pubmed/16127463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24898 |
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