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Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma

Proviral integration site for Moloney murine leukemia virus (Pim) kinases are serine/threonine/tyrosine kinases and oncoproteins that promote tumor progression. Three isoforms of Pim kinases have been identified and are known to phosphorylate numerous substrates, with regulatory functions in transcr...

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Detalhes bibliográficos
Main Authors: Yang, Qingshan, Chen, Lisa S., Neelapu, Sattva S., Miranda, Roberto N., Medeiros, L. Jeffrey, Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482859/
https://ncbi.nlm.nih.gov/pubmed/22955922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-412643
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