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Idelalisib impacts cell growth through inhibiting translation regulatory mechanisms in mantle cell lymphoma
PURPOSE: PI3 Kinase is a critical node in the B-cell receptor pathway which is responsible for survival and proliferation of B-cell malignancies. Idelalisib, a PI3Kδ-isoform specific inhibitor, has been approved to treat B-cell malignancies. While biological activity of the drug has been evaluated,...
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| Publicat a: | Clin Cancer Res |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433851/ https://ncbi.nlm.nih.gov/pubmed/27342398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3135 |
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