TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8(+) T-cell differentiation

CD8(+) T-cell development in the thymus generates a predominant population of conventional naive cells, along with minor populations of “innate” T cells that resemble memory cells. Recent studies analyzing a variety of KO or knock-in mice have indicated that impairments in the T-cell receptor (TCR)...

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Hlavní autoři: Nayar, Ribhu, Enos, Megan, Prince, Amanda, Shin, HyunMu, Hemmers, Saskia, Jiang, Jian-kang, Klein, Ulf, Thomas, Craig J., Berg, Leslie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478592/
https://ncbi.nlm.nih.gov/pubmed/23011795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205742109
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