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T-Cell Signaling Regulated by the Tec Family Kinase, Itk

The Tec family tyrosine kinases regulate lymphocyte development, activation, and differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-γ. This review highlights recent advances in our understanding of Itk kinase...

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Bibliographic Details
Main Authors: Andreotti, Amy H., Schwartzberg, Pamela L., Joseph, Raji E., Berg, Leslie J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890196/
https://ncbi.nlm.nih.gov/pubmed/20519342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a002287
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