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Activation of the Tec kinase ITK controls graded IRF4 expression in response to variations in TCR signal strength
TCR signal strength is critical for CD8(+) T cell clonal expansion after antigen stimulation. Levels of the transcription factor IRF4 control the magnitude of this process through induction of genes involved in proliferation and glycolytic metabolism. The signaling mechanism connecting graded TCR si...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7343623/ https://ncbi.nlm.nih.gov/pubmed/32493815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900853 |
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