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Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
Th9 cells produce interleukin (IL)-9, a cytokine implicated in allergic asthma and autoimmunity. Here we show that Itk, a mediator of T cell receptor signalling required for Th2 immune responses and the development of asthma, is a positive regulator of Th9 differentiation. In a model of allergic lun...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782063/ https://ncbi.nlm.nih.gov/pubmed/26936133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10857 |
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