Differential expression of IL-17A and IL-17F is coupled to TCR signaling via Itk-mediated regulation of NFATc1

Th17 cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 differentiation is relatively unknown. We demonstrate that CD4(+) T cells deficient in Itk, a tyrosine kinase required for full TCR-induced activation of PLC-γ, exhibit decrease...

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Detaylı Bibliyografya
Asıl Yazarlar: Gomez-Rodriguez, Julio, Sahu, Nisebita, Handon, Robin, Davidson, Todd S., Anderson, Stacie M., Kirby, Martha R., August, Avery, Schwartzberg, Pamela L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767186/
https://ncbi.nlm.nih.gov/pubmed/19818650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.009
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