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Differential expression of IL-17A and IL-17F is coupled to TCR signaling via Itk-mediated regulation of NFATc1
Th17 cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 differentiation is relatively unknown. We demonstrate that CD4(+) T cells deficient in Itk, a tyrosine kinase required for full TCR-induced activation of PLC-γ, exhibit decrease...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767186/ https://ncbi.nlm.nih.gov/pubmed/19818650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.009 |
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