Acetaminophen-induced Liver Injury in Rats and Mice: Comparison of Protein Adducts, Mitochondrial Dysfunction, and Oxidative Stress in the Mechanism of Toxicity

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the West. In mice, APAP hepatotoxicity can be rapidly induced with a single dose. Because it is both clinically relevant and experimentally convenient, APAP intoxication has become a popular model of liver injury. Early...

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Huvudupphovsmän: McGill, Mitchell R., Williams, C. David, Xie, Yuchao, Ramachandran, Anup, Jaeschke, Hartmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478469/
https://ncbi.nlm.nih.gov/pubmed/22980195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.08.015
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