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Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases
Natural product-derived bengamides possess potent antiproliferative activity and target human methionine aminopeptidases (MetAPs) for their cellular effects. Several derivatives were designed, synthesized, and evaluated as MetAP inhibitors. Here, we present four new X-ray structures of human MetAP1...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470909/ https://ncbi.nlm.nih.gov/pubmed/22913487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008695 |
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