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Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

In autosomal-dominant polycystic kidney disease (ADPKD), renal cysts develop by aberrant epithelial cell proliferation and transepithelial fluid secretion. We previously showed that ouabain increases proliferation of cultured human ADPKD cells via stimulation of the EGF receptor (EGFR)-Src-MEK/ERK s...

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書誌詳細
主要な著者: Jansson, Kyle, Nguyen, Anh-Nguyet T., Magenheimer, Brenda S., Reif, Gail A., Aramadhaka, Lavakumar Reddy, Bello-Reuss, Elsa, Wallace, Darren P., Calvet, James P., Blanco, Gustavo
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469686/
https://ncbi.nlm.nih.gov/pubmed/22859406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00677.2011
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