Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells

The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the ADPKD phenotype includes cell de-differentiation and epithelial to mesenchymal transition (EMT). Here, we determined whether physiological conc...

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Pubblicato in:Exp Cell Res
Autori principali: Venugopal, Jessica, McDermott, Jeffrey, Sanchez, Gladis, Sharma, Madhulika, Barbosa, Leandro, Reif, Gail A., Wallace, Darren P., Blanco, Gustavo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497755/
https://ncbi.nlm.nih.gov/pubmed/28385574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2017.04.001
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