Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells

The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the ADPKD phenotype includes cell de-differentiation and epithelial to mesenchymal transition (EMT). Here, we determined whether physiological conc...

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Detalhes bibliográficos
Publicado no:Exp Cell Res
Main Authors: Venugopal, Jessica, McDermott, Jeffrey, Sanchez, Gladis, Sharma, Madhulika, Barbosa, Leandro, Reif, Gail A., Wallace, Darren P., Blanco, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497755/
https://ncbi.nlm.nih.gov/pubmed/28385574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2017.04.001
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