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Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen. We previously showed that physiological amounts of ouabain enhance cAMP-dependent fluid secretion and cyst growth of human ADPKD cyst epithelial cells in cult...

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Publicat a:J Membr Biol
Autors principals: Jansson, Kyle, Venugopal, Jessica, Sánchez, Gladis, Magenheimer, Brenda S., Reif, Gail A., Wallace, Darren P., Calvet, James P., Blanco, Gustavo
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672947/
https://ncbi.nlm.nih.gov/pubmed/26289599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-015-9832-7
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