Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

In autosomal-dominant polycystic kidney disease (ADPKD), renal cysts develop by aberrant epithelial cell proliferation and transepithelial fluid secretion. We previously showed that ouabain increases proliferation of cultured human ADPKD cells via stimulation of the EGF receptor (EGFR)-Src-MEK/ERK s...

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Main Authors: Jansson, Kyle, Nguyen, Anh-Nguyet T., Magenheimer, Brenda S., Reif, Gail A., Aramadhaka, Lavakumar Reddy, Bello-Reuss, Elsa, Wallace, Darren P., Calvet, James P., Blanco, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469686/
https://ncbi.nlm.nih.gov/pubmed/22859406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00677.2011
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