Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation

The Na-K-ATPase is part of a cell signaling complex, the Na-K-ATPase signalosome, which upon activation by the hormone ouabain regulates the function of different cell types. We previously showed that ouabain induces proliferation of epithelial cells derived from renal cysts of patients with autosom...

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Main Authors: Nguyen, Anh-Nguyet T., Jansson, Kyle, Sánchez, Gladis, Sharma, Madhulika, Reif, Gail A., Blanco, Gustavo, Wallace, Darren P.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191809/
https://ncbi.nlm.nih.gov/pubmed/21697238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00095.2011
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