Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

In autosomal-dominant polycystic kidney disease (ADPKD), renal cysts develop by aberrant epithelial cell proliferation and transepithelial fluid secretion. We previously showed that ouabain increases proliferation of cultured human ADPKD cells via stimulation of the EGF receptor (EGFR)-Src-MEK/ERK s...

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Hlavní autoři: Jansson, Kyle, Nguyen, Anh-Nguyet T., Magenheimer, Brenda S., Reif, Gail A., Aramadhaka, Lavakumar Reddy, Bello-Reuss, Elsa, Wallace, Darren P., Calvet, James P., Blanco, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469686/
https://ncbi.nlm.nih.gov/pubmed/22859406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00677.2011
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