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Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid

Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyren...

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Detalhes bibliográficos
Main Authors: Wood, Alexander W., Huang, Mou-Tuan, Chang, Richard L., Newmark, Harold L., Lehr, Roland E., Yagi, Haruhiko, Sayer, Jane M., Jerina, Donald M., Conney, Allan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 1982
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC346934/
https://ncbi.nlm.nih.gov/pubmed/6752950
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