Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

The tumorigenicities of benzo[a]pyrene and each optical enantiomer of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides derived from trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene were tested by sequential intraperitoneal injection of mice with 1,2, and 4 nmol, or with 2, 4, and 8 nmol of eac...

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Bibliographic Details
Published in:	Proc Natl Acad Sci U S A
Main Authors:	Buening, M K, Wislocki, P G, Levin, W, Yagi, H, Thakker, D R, Akagi, H, Koreeda, M, Jerina, D M, Conney, A H
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1978
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/281685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5358
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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

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