Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

The tumorigenicities of benzo[a]pyrene and each optical enantiomer of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides derived from trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene were tested by sequential intraperitoneal injection of mice with 1,2, and 4 nmol, or with 2, 4, and 8 nmol of eac...

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Hauptverfasser: Buening, M K, Wislocki, P G, Levin, W, Yagi, H, Thakker, D R, Akagi, H, Koreeda, M, Jerina, D M, Conney, A H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1978
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC392962/
https://ncbi.nlm.nih.gov/pubmed/281685
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