Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.

Tumorigenic activities of the (7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro derivatives of benzo[a]pyrene [(+)-B[a]P diol epoxide-2] and 6-fluorobenzo[a]pyrene (6-FB[a]P diol epoxide-2) were evaluated in newborn CD-1 mice. A total dose of 14 nmol of either diol epoxide was administered...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Chang, R L, Wood, A W, Conney, A H, Yagi, H, Sayer, J M, Thakker, D R, Jerina, D M, Levin, W
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1987
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299600/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8633
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