Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid

Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyren...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wood, Alexander W., Huang, Mou-Tuan, Chang, Richard L., Newmark, Harold L., Lehr, Roland E., Yagi, Haruhiko, Sayer, Jane M., Jerina, Donald M., Conney, Allan H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1982
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6752950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.18.5513
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