Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are req...

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Detalhes bibliográficos
Main Authors: Gurung, Prajwal, Malireddi, R. K. Subbarao, Anand, Paras K., Demon, Dieter, Walle, Lieselotte Vande, Liu, Zhiping, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464552/
https://ncbi.nlm.nih.gov/pubmed/22898816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401406
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