FADD and caspase-8 mediate priming and activation of the canonical and non-canonical Nlrp3 inflammasomes

The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its activation are enigmatic. Here, we show that loss of FADD or caspase-8 in a RIP3-deficient background - but not RIP3-deficiency alone - hampered transcriptional priming and post-translational activation of the c...

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Bibliografiske detaljer
Main Authors: Gurung, Prajwal, Anand, Paras K., Subbarao Malireddi, R. K., Walle, Lieselotte Vande, Van Opdenbosch, Nina, Dillon, Christopher P., Weinlich, Ricardo, Green, Douglas R., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933570/
https://ncbi.nlm.nih.gov/pubmed/24453255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302839
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