Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Despite its clinical importance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain enigmatic. Here we show that deletion of the inflammasome adaptor ASC in BALB/c mice and in C57BL/6 macrophages expressing a functional NLRP1b prevents anthrax lethal toxin (LeT...

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Detaylı Bibliyografya
Asıl Yazarlar: Van Opdenbosch, Nina, Gurung, Prajwal, Vande Walle, Lieselotte, Fossoul, Amelie, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926011/
https://ncbi.nlm.nih.gov/pubmed/24492532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4209
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