Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Despite its clinical importance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain enigmatic. Here we show that deletion of the inflammasome adaptor ASC in BALB/c mice and in C57BL/6 macrophages expressing a functional NLRP1b prevents anthrax lethal toxin (LeT...

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Main Authors: Van Opdenbosch, Nina, Gurung, Prajwal, Vande Walle, Lieselotte, Fossoul, Amelie, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926011/
https://ncbi.nlm.nih.gov/pubmed/24492532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4209
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