Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Despite its clinical importance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain enigmatic. Here we show that deletion of the inflammasome adaptor ASC in BALB/c mice and in C57BL/6 macrophages expressing a functional NLRP1b prevents anthrax lethal toxin (LeT...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Van Opdenbosch, Nina, Gurung, Prajwal, Vande Walle, Lieselotte, Fossoul, Amelie, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926011/
https://ncbi.nlm.nih.gov/pubmed/24492532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4209
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