Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are req...

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Detalles Bibliográficos
Autores principales: Gurung, Prajwal, Malireddi, R. K. Subbarao, Anand, Paras K., Demon, Dieter, Walle, Lieselotte Vande, Liu, Zhiping, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464552/
https://ncbi.nlm.nih.gov/pubmed/22898816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401406
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