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SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation

The NLRP3 inflammasome is a multimeric protein complex assembled in response to a wide array of pathogens and danger-associated molecular patterns. Despite the ability of NLRP3 to respond to diverse cues, the mechanisms controlling assembly of this complex are contested. Recently published studies s...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Gurung, Prajwal, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340749/
https://ncbi.nlm.nih.gov/pubmed/25637014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402951
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