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Proteolytic inactivation of poly (ADP-ribose) polymerase 1 (PARP1) by the Nlrp3 and Nlrc4 inflammasomes
Caspase-mediated cleavage of the DNA damage sensor poly(adenosine 5′-diphosphate-ribose) polymerase 1 (PARP1) is a hallmark of apoptosis. However, whether PARP1 is processed during pyroptosis, a specialized cell death program that occurs upon activation of caspase-1 in inflammasome complexes remains...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104018/ https://ncbi.nlm.nih.gov/pubmed/20713892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001512 |
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