Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined here as an alternative. After comparing fluorescence polarization (FP), homo...

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Detaylı Bibliyografya
Asıl Yazarlar: Mukherjee, Sourav, Hanson, Alicia M., Shadrick, William R., Ndjomou, Jean, Sweeney, Noreena L., Hernandez, John J., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Heck, Julie A., Arnold, Leggy A., Schoenen, Frank J., Frick, David N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2012
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458564/
https://ncbi.nlm.nih.gov/pubmed/22740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks623
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