Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined here as an alternative. After comparing fluorescence polarization (FP), homo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mukherjee, Sourav, Hanson, Alicia M., Shadrick, William R., Ndjomou, Jean, Sweeney, Noreena L., Hernandez, John J., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Heck, Julie A., Arnold, Leggy A., Schoenen, Frank J., Frick, David N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2012
Gaiak:
Nucleic Acid Enzymes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458564/
https://ncbi.nlm.nih.gov/pubmed/22740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks623
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