Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined here as an alternative. After comparing fluorescence polarization (FP), homo...

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Detalles Bibliográficos
Main Authors: Mukherjee, Sourav, Hanson, Alicia M., Shadrick, William R., Ndjomou, Jean, Sweeney, Noreena L., Hernandez, John J., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Heck, Julie A., Arnold, Leggy A., Schoenen, Frank J., Frick, David N.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458564/
https://ncbi.nlm.nih.gov/pubmed/22740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks623
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