Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined here as an alternative. After comparing fluorescence polarization (FP), homo...

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Detalhes bibliográficos
Main Authors: Mukherjee, Sourav, Hanson, Alicia M., Shadrick, William R., Ndjomou, Jean, Sweeney, Noreena L., Hernandez, John J., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Heck, Julie A., Arnold, Leggy A., Schoenen, Frank J., Frick, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458564/
https://ncbi.nlm.nih.gov/pubmed/22740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks623
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