Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined here as an alternative. After comparing fluorescence polarization (FP), homo...

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Библиографические подробности
Главные авторы: Mukherjee, Sourav, Hanson, Alicia M., Shadrick, William R., Ndjomou, Jean, Sweeney, Noreena L., Hernandez, John J., Bartczak, Diana, Li, Kelin, Frankowski, Kevin J., Heck, Julie A., Arnold, Leggy A., Schoenen, Frank J., Frick, David N.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Nucleic Acid Enzymes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458564/
https://ncbi.nlm.nih.gov/pubmed/22740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks623
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