Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

PURPOSE: Pyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin poly...

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Main Authors: Synold, Timothy W., Xi, Bixin, Wu, Jun, Yen, Yun, Li, Benjamin C., Yang, Fei, Phillips, John W., Nickols, Nicholas G., Dervan, Peter B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer-Verlag 2012
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3456924/
https://ncbi.nlm.nih.gov/pubmed/22907527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1954-3
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