Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

Pyrrole-imidazole (Py–Im) polyamides are synthetic non-genotoxic minor groove-binding small molecules. We hypothesized that Py–Im polyamides can modulate the cellular response to ionizing radiation. Pre-treatment of cells with a Py-Im polyamide prior to exposure to ionizing radiation resulted in a d...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Diaz-Perez, Silvia, Kane, Nathanael, Kurmis, Alexis A., Yang, Fei, Kummer, Nicolas T., Dervan, Peter B., Nickols, Nicholas G.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929528/
https://ncbi.nlm.nih.gov/pubmed/29715291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196803
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