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A pyrrole-imidazole polyamide is active against enzalutamide-resistant prostate cancer

The LREX’ prostate cancer model is resistant to the antiandrogen enzalutamide via activation of an alternative nuclear hormone receptor (NHR), glucocorticoid receptor (GR), which has similar DNA binding specificity to the androgen receptor (AR). Small molecules that target DNA to interfere with prot...

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Foilsithe in:Cancer Res
Main Authors: Kurmis, Alexis A., Yang, Fei, Welch, Timothy R., Nickols, Nicholas G., Dervan, Peter B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480898/
https://ncbi.nlm.nih.gov/pubmed/28360139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2503
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