Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit

[Image: see text] A hairpin pyrrole-imidazole polyamide (1) targeted to the androgen receptor consensus half-site was found to exert antitumor effects against prostate cancer xenografts. A previous animal study showed that 1, which has a chiral amine at the α-position of the γ-aminobutyric acid turn...

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Bibliografiske detaljer
Main Authors: Yang, Fei, Nickols, Nicholas G., Li, Benjamin C., Szablowski, Jerzy O., Hamilton, Shari R., Meier, Jordan L., Wang, Chieh-Mei, Dervan, Peter B.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788622/
https://ncbi.nlm.nih.gov/pubmed/24015881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401100s
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