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Tumor Xenograft Uptake of a Pyrrole–Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted

[Image: see text] Subcutaneous xenografts represent a popular approach to evaluate efficacy of prospective molecular therapeutics in vivo. In the present study, the C-14 labeled radioactive pyrrole–imidazole (Py-Im) polyamide 1, targeted to the 5′-WGWWCW-3′ DNA sequence, was evaluated with regard to...

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Bibliografiska uppgifter
Huvudupphovsmän: Raskatov, Jevgenij A., Szablowski, Jerzy O., Dervan, Peter B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207538/
https://ncbi.nlm.nih.gov/pubmed/25238175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500964c
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