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Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide
Gene regulation by DNA binding small molecules could have important therapeutic applications. This study reports the investigation of a DNA-binding pyrrole-imidazole polyamide targeted to bind the DNA sequence 5′-WGGWWW-3′ with reference to its potency in a subcutaneous xenograft tumor model. The mo...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479560/ https://ncbi.nlm.nih.gov/pubmed/22988074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214267109 |
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