Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide

Gene regulation by DNA binding small molecules could have important therapeutic applications. This study reports the investigation of a DNA-binding pyrrole-imidazole polyamide targeted to bind the DNA sequence 5′-WGGWWW-3′ with reference to its potency in a subcutaneous xenograft tumor model. The mo...

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Bibliografiske detaljer
Main Authors: Raskatov, Jevgenij A., Nickols, Nicholas G., Hargrove, Amanda E., Marinov, Georgi K., Wold, Barbara, Dervan, Peter B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479560/
https://ncbi.nlm.nih.gov/pubmed/22988074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214267109
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