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Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice
PURPOSE: Pyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin poly...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3456924/ https://ncbi.nlm.nih.gov/pubmed/22907527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1954-3 |
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