SPHINGOSINE KINASE TYPE 1 INHIBITION REVEALS RAPID TURNOVER OF CIRCULATING SPHINGOSINE 1-PHOSPHATE

Sphingosine 1-phosphate (S1P) is a signaling molecule involved in a host of cellular and physiological functions – most notably cell survival and migration. S1P, which signals via a set of five G protein coupled receptors (S1P1–5), is formed by the action of two sphingosine kinases (SphKs) from sphi...

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Detalhes bibliográficos
Main Authors: Kharel, Yugesh, Mathews, Thomas P., Gellett, Amanda M., Tomsig, Jose L., Kennedy, Perry C., Moyer, Morgan L., Macdonald, Timothy L., Lynch, Kevin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443603/
https://ncbi.nlm.nih.gov/pubmed/21848514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110817
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