Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative alterations is unknown. We conducted a study of phenotypic and molecular alterations in highly fractionated stem and progenitor populations in a varie...

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Autori principali: Will, Britta, Zhou, Li, Vogler, Thomas O., Ben-Neriah, Susanna, Schinke, Carolina, Tamari, Roni, Yu, Yiting, Bhagat, Tushar D., Bhattacharyya, Sanchari, Barreyro, Laura, Heuck, Christoph, Mo, Yonkai, Parekh, Samir, McMahon, Christine, Pellagatti, Andrea, Boultwood, Jacqueline, Montagna, Cristina, Silverman, Lewis, Maciejewski, Jaroslaw, Greally, John M., Ye, B. Hilda, List, Alan F., Steidl, Christian, Steidl, Ulrich, Verma, Amit
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437595/
https://ncbi.nlm.nih.gov/pubmed/22753872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-399683
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