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Oxidation of Dihydrotestosterone by Human Cytochromes P450 19A1 and 3A4

Dihydrotestosterone is a more potent androgen than testosterone and plays an important role in endocrine function. We demonstrated that, like testosterone, dihydrotestosterone can be oxidized by human cytochrome P450 (P450) 19A1, the steroid aromatase. The products identified include the 19-hydroxy-...

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Détails bibliographiques
Auteurs principaux: Cheng, Qian, Sohl, Christal D., Yoshimoto, Francis K., Guengerich, F. Peter
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436178/
https://ncbi.nlm.nih.gov/pubmed/22773874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390047
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