Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regul...

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Main Authors: Shyp, Viktoriya, Tankov, Stoyan, Ermakov, Andrey, Kudrin, Pavel, English, Brian P, Ehrenberg, Måns, Tenson, Tanel, Elf, Johan, Hauryliuk, Vasili
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432798/
https://ncbi.nlm.nih.gov/pubmed/22814757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.106
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